Innovating manufacturing and technologies in Cumbria

Brennan, Sam (2025) Innovating manufacturing and technologies in Cumbria. In: Innovating Manufacturing and Technologies in Cumbria, 19 November 2025, University of Cumbria, Brampton Road Campus, Carlisle, UK. (Unpublished)

Preview

PDF (slides) - Presentation Available under License CC BY-NC Download (716kB) | Preview

Abstract

Although conventional drugs such as the penicillin’s led the golden age of antimicrobial chemotherapy, the alarming rise in antimicrobial drug resistance due to its single mode of action, means alternative approaches to infection control and disinfection needs to be rapidly considered [1]. In contrast, photoantimicrobials produce highly reactive oxygen species and thus offers both multiple and variable sites of action at the pathogenic target. This project seeks to develop a new range of near-infrared squarylium dyes capable of producing a large amount of reactive oxygen species to cause a localised photobiocidal response in pathogenic targets with potential clinical and industrial uses [2]. Preliminary microbial data highlights excellent MIC in the µM range.

References:
1. Wainwright, M., et al., Photoantimicrobials-are we afraid of the light? The Lancet. Infectious diseases, 2017. 17(2): p. e49-e55.
2. Adnane, F., E. El-Zayat, and H.M. Fahmy, The combinational application of photodynamic therapy and nanotechnology in skin cancer treatment: A review. Tissue and Cell, 2022. 77: p.101856.

Presentation given by University of Cumbria's Samuel Brennan, Lecturer of Chemistry. Part of an overall project: Light-Activated Lifelines: Phototherapeutic Dyes Against Antimicrobial Resistance.

Some of Cumbria’s key businesses and organisations gathered at the University of Cumbria's Brampton Road campus in Carlisle for this event, hosted by the University's Research and Knowledge Exchange (RKE) colleagues. The event sought to bring together innovators, industry leaders and stakeholders to explore opportunities in manufacturing and technology across the region, and marked an important step in strengthening research and knowledge exchange opportunities between the University of Cumbria and businesses.

Item Type:	Conference or Workshop Item (Lecture)
Departments:	Institute of Science and Environment > STEM
Depositing User:	Anna Lupton
Date Deposited:	05 Dec 2025 14:46
Last Modified:	05 Dec 2025 14:48
URI:	https://insight.cumbria.ac.uk/id/eprint/9227

Downloads