Systematic review on the role of microfluidic platforms in advancing scalable and precise microbial bioprocessing

Alpural, Alperen, Kimiz‐Gebologlu, Ilgin, Parekh, Mayur, Imamoglu, Esra, Ali, Zulfiqur ORCID: https://orcid.org/0000-0001-9884-8146 and Yesil‐Celiktas, Ozlem (2025) Systematic review on the role of microfluidic platforms in advancing scalable and precise microbial bioprocessing. Engineering in Life Sciences, 25 (9). e70034.

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Abstract

Microbial bioprocessing is a key technology for the production of a wide range of biomolecules, including proteins, enzymes, antibiotics, and other bioactive compounds. In recent years, there has been an increasing interest in using microfluidic platforms for bioprocessing, due to the ability to precisely control and manipulate fluids at the microscale. Microfluidics offers a transformative platform for the manufacturing of biomolecules intended for clinical applications by addressing key technical challenges in scalability, precision, reproducibility, and the ability to study complex biological systems. In this review, various methods used to fabricate microfluidic platforms and the current state-of-the-art in the synthesis/production of biopharmaceuticals, polymers, bioactive compounds, and real-time monitoring in microscale bioprocesses are discussed. Additionally, the future trends and directions are highlighted. Overall, we envisage the utilization of microfluidic platforms to advance the field of microbial bioprocessing and applications in the biomedical field.

Item Type:	Article
Journal / Publication Title:	Engineering in Life Sciences
Publisher:	Wiley
ISSN:	1618-2863
Departments:	Professional Services > Vice Chancellor's Office
Additional Information:	Zulfiqur Ali, Professor and Pro Vice Chancellor (Research and Knowledge Exchange), University of Cumbria, UK. This is an open access article under the terms of the Creative Commons Attribution-Non Commercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Depositing User:	Insight Administrator
SWORD Depositor:	Insight Administrator
Date Deposited:	13 Sep 2025 18:02
Last Modified:	14 Sep 2025 08:00
URI:	https://insight.cumbria.ac.uk/id/eprint/9032

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