Sprint interval training (SIT) reduces serum epidermal growth factor (EGF), but not other inflammatory cytokines in trained older men

Yasar, Zerbu ORCID: https://orcid.org/0000-0001-8838-7286 , Elliott, Bradley T., Kyriakidou, Yvoni, Nwokoma, Chiazor T., Postlethwaite, Ruth D. ORCID: https://orcid.org/0000-0003-3888-9338 , Gaffney, Christopher J., Dewhurst, Susan and Hayes, Lawrence ORCID: https://orcid.org/0000-0002-6654-0072 (2021) Sprint interval training (SIT) reduces serum epidermal growth factor (EGF), but not other inflammatory cytokines in trained older men. European Journal of Applied Physiology .

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Abstract

Purpose: The present study aimed to investigate the effect of age on circulating pro- and anti-inflammatory cytokines and growth factors. A secondary aim was to investigate whether a novel sprint interval training (SIT) intervention (3 × 20 s ‘all out’ static sprints, twice a week for 8 weeks) would affect inflammatory markers in older men.

Methods: Nine older men [68 (1) years] and eleven younger men [28 (2) years] comprised the younger group. Aerobic fitness and inflammatory markers were taken at baseline for both groups and following the SIT intervention for the older group.

Results: Interleukin (IL)-8, vascular endothelial growth factor (VEGF), and monocyte chemoattractant protein-1 (MCP-1) were unchanged for the older and younger groups at baseline (IL-8, p = 0.819; MCP-1, p = 0.248; VEGF, p = 0.264). Epidermal growth factor (EGF) was greater in the older group compared to the younger group at baseline [142 (20) pg mL −1 and 60 (12) pg mL −1 , respectively, p = 0.001, Cohen's d = 1.64]. Following SIT, older men decreased EGF to 100 (12) pg mL −1 which was similar to that of young men who did not undergo training ( p = 0.113, Cohen's d = 1.07).

Conclusion: Older aerobically trained men have greater serum EGF than younger aerobically trained men. A novel SIT intervention in older men can shift circulating EGF towards trained younger concentrations. As lower EGF has previously been associated with longevity in C. elegans , the manipulative effect of SIT on EGF in healthy ageing in the human may be of further interest.

Item Type:	Article
Journal / Publication Title:	European Journal of Applied Physiology
Publisher:	Springer Nature
ISSN:	1439-6319
Departments:	Institute of Science and Environment > Outdoor Studies
Depositing User:	Christian Stretton
Date Deposited:	19 Mar 2021 11:30
Last Modified:	13 Jan 2024 12:00
URI:	https://insight.cumbria.ac.uk/id/eprint/6006

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