Evaluation of an MRI-based protocol for cell implantation in four patients with Huntington's disease

Watts, C., Donovan, Tim ORCID: https://orcid.org/0000-0003-4112-861X , Gillard, Jonathan H., Antoun, N.M., Burnstein, Rowan M., Menon, David K., Carpenter, T. Adrian, Fryer, Tim, Thomas, D.G. and Pickard, John D. (2003) Evaluation of an MRI-based protocol for cell implantation in four patients with Huntington's disease. Cell Transplantation, 12 (7). pp. 697-704. Full text not available from this repository.

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Abstract

The purpose of this study was to evaluate our surgical protocol for the preparation and delivery of suspensions of fetal tissue into the diseased human brain. We implanted suspensions of human fetal striatal anlage into the right caudate and putamen of four patients with Huntington's disease. Postoperative 3 tesla MR imaging confirmed accurate graft placement. Variability in graft survival was noted and the MR signal changes over 6 months revealed persistent hyperintense signal on T2-weighted images. Our results are consistent with those described by other groups and indicate that our surgical protocol is safe, accurate, and reproducible.

Item Type:	Article
Journal / Publication Title:	Cell Transplantation
Publisher:	Cognizant Communication Corporation
ISSN:	1555-3892
Departments:	Academic Departments > Medical & Sport Sciences (MSS) > Health and Medical Sciences
Depositing User:	Insight Administrator
Date Deposited:	17 Oct 2011 08:23
Last Modified:	11 Jan 2024 18:30
URI:	https://insight.cumbria.ac.uk/id/eprint/1036