Combined sprint and resistance training abrogates age differences in somatotropic hormones

Sellami, Maha, Wissem, Dhabi, Hayes, Lawrence, Padulo, Johnny, Rhibi, Fatma, Djemail, Hanen and Chaouachi, Anis (2017) Combined sprint and resistance training abrogates age differences in somatotropic hormones. PLoS ONE, 12 (8). e0183184.

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Abstract

The aim of this investigation was to compare serum growth hormone (GH), insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-binding protein-3 (IGFBP-3) in response to a combined sprint and resistance training (CSRT) program in young and middle-aged men. Thirty-eight healthy, moderately trained military soldiers participated in this study. Young and middle-aged men were randomly assigned to, a young training group (YT=10, 21.4±1.2 yrs) or a young control group (YC=9, 21.6±1.8 yrs), a middle-aged training group (MAT=10, 40.4±2.1 yrs) or a middle-aged control group (MAC=9, 40.5±1.8 yrs). Participants performed the Wingate Anaerobic Test (WAnT) before and after a 13-week CSRT program (three sessions per week). Blood samples were collected at rest, after warm-up, immediately post-WAnT, and 10 min post-WAnT. CSRT induced increases in GH at rest and in response to the WAnT in YT and MAT (P<0.05). CSRT-induced increases were observed for IGF-1 and IGFBP-3 at rest in MAT only (P<0.05). Pre-training, GH, IGF-1 and IGFBP-3 were significantly higher at rest and in response to the WAnT in young participants as compared to their middle-aged counterparts (P<0.05). Post-training, YT and MAT had comparable basal GH (P>0.05). In response to the WAnT, amelioration of the age-effect was observed between YT and MAT for IGF-1 and IGF-1/IGFBP-3 ratio following CSRT (P>0.05). These data suggest that CSRT increases the activity of the GH/IGF-1 axis at rest and in response to the WAnT in young and middle-aged men. In addition, CSRT reduces the normal age-related decline of somatotropic hormones in middle-age men.

Item Type:	Article
Journal / Publication Title:	PLoS ONE
Publisher:	Public Library of Science
ISSN:	1932-6203
Departments:	Academic Departments > Medical & Sport Sciences (MSS) > Sports and Physical Activity
Depositing User:	Lawrence Hayes
Date Deposited:	20 Sep 2017 15:23
Last Modified:	06 Jul 2021 10:15
URI:	https://insight.cumbria.ac.uk/id/eprint/3180

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