Combined sprint and resistance training abrogates age differences in somatotropic hormones

Sellami, Maha, Wissem, Dhabi, Hayes, Lawrence ORCID: https://orcid.org/0000-0002-6654-0072, Padulo, Johnny, Rhibi, Fatma, Djemail, Hanen and Chaouachi, Anis (2017) Combined sprint and resistance training abrogates age differences in somatotropic hormones. PLoS ONE, 12 (8). e0183184.

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Abstract

The aim of this investigation was to compare serum growth hormone (GH), insulin-like growth factor-1 (IGF-1) and insulin-like growth factor-binding protein-3 (IGFBP-3) in response to a combined sprint and resistance training (CSRT) program in young and middle-aged men. Thirty-eight healthy, moderately trained military soldiers participated in this study. Young and middle-aged men were randomly assigned to, a young training group (YT=10, 21.4±1.2 yrs) or a young control group (YC=9, 21.6±1.8 yrs), a middle-aged training group (MAT=10, 40.4±2.1 yrs) or a middle-aged control group (MAC=9, 40.5±1.8 yrs). Participants performed the Wingate Anaerobic Test (WAnT) before and after a 13-week CSRT program (three sessions per week). Blood samples were collected at rest, after warm-up, immediately post-WAnT, and 10 min post-WAnT. CSRT induced increases in GH at rest and in response to the WAnT in YT and MAT (P<0.05). CSRT-induced increases were observed for IGF-1 and IGFBP-3 at rest in MAT only (P<0.05). Pre-training, GH, IGF-1 and IGFBP-3 were significantly higher at rest and in response to the WAnT in young participants as compared to their middle-aged counterparts (P<0.05). Post-training, YT and MAT had comparable basal GH (P>0.05). In response to the WAnT, amelioration of the age-effect was observed between YT and MAT for IGF-1 and IGF-1/IGFBP-3 ratio following CSRT (P>0.05). These data suggest that CSRT increases the activity of the GH/IGF-1 axis at rest and in response to the WAnT in young and middle-aged men. In addition, CSRT reduces the normal age-related decline of somatotropic hormones in middle-age men.

Item Type:	Article
Journal / Publication Title:	PLoS ONE
Publisher:	Public Library of Science
ISSN:	1932-6203
Departments:	Academic Departments > Medical & Sport Sciences (MSS) > Sports and Physical Activity
Depositing User:	Lawrence Hayes
Date Deposited:	20 Sep 2017 15:23
Last Modified:	06 Jul 2021 10:15
URI:	https://insight.cumbria.ac.uk/id/eprint/3180

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