Normal pressure hydrocephalus and cerebral blood flow: a PET study of baseline values

Owler, Brian K., Momjian, Shahan, Czosnyka, Zofia, Czosnyka, Marek, Pena, Alonso, Harris, Neil G., Smielewski, Piotr, Fryer, Tim, Donovan, Tim ORCID logo ORCID: , Coles, Jonathan, Carpenter, Adrian and Pickard, John D. (2004) Normal pressure hydrocephalus and cerebral blood flow: a PET study of baseline values. Journal of Cerebral Blood Flow & Metabolism, 24 (1). pp. 17-23. Full text not available from this repository.

(Contact the author)
Official URL:


Regional cerebral blood flow (CBF) was studied with O15-water positron emission tomography and anatomic region-of-interest analysis on coregistered magnetic resonance in patients with idiopathic (n = 12) and secondary (n = 5) normal pressure hydrocephalus (NPH). Mean CBF was compared with values obtained from healthy volunteers (n = 12) and with clinical parameters. Mean CBF was significantly decreased in the cerebrum and cerebellum of patients with NPH. The regional analysis demonstrated that CBF was reduced in the basal ganglia and the thalamus but not in white matter regions. The results suggest that the role of the basal ganglia and thalamus in NPH may be more prominent than currently appreciated. The implications for theories regarding the pathogenesis of NPH are discussed.

Item Type: Article
Journal / Publication Title: Journal of Cerebral Blood Flow & Metabolism
Publisher: SAGE Publications for International Society for Cerebral Blood Flow and Metabolism / Nature Publishing Group
ISSN: 1559-7016
Departments: Academic Departments > Medical & Sport Sciences (MSS) > Health and Medical Sciences
Depositing User: Insight Administrator
Date Deposited: 14 Oct 2011 14:56
Last Modified: 11 Jan 2024 18:45
Edit Item