Aerobically trained older adults show impaired resting, but preserved exercise-induced circulating progenitor cell count, which was not improved by sprint interval training

Yasar, Zerbu ORCID: https://orcid.org/0000-0001-8838-7286 , Ross, Mark D., Gaffney, Christopher J., Postlethwaite, Ruth D., Wilson, Russell and Hayes, Lawrence ORCID: https://orcid.org/0000-0002-6654-0072 (2023) Aerobically trained older adults show impaired resting, but preserved exercise-induced circulating progenitor cell count, which was not improved by sprint interval training. Pflügers Archiv European Journal of Physiology, 475 (4). pp. 465-475.

Preview

PDF - Published Version Available under License CC BY Download (1MB) | Preview

Abstract

Older adults exhibit a reduced number and function of CD34 + circulating progenitor cells (CPC), a known risk factor for cardiovascular disease. Exercise promotes the mobilisation of CPCs from bone marrow, so whether ageing per se or physical inactivity in older age reduces CPCs is unknown. Thus, this study examined the effect of age on resting and exercise-induced changes in CPCs in aerobically trained adults and the effect of 8 weeks of sprint interval training (SIT) on resting and exercise-induced CPCs in older adults. Twelve young (22-34 years) and nine older (63-70 years) adults participated in the study. Blood was sampled pre and immediately post a graded exercise test to exhaustion in both groups. Older participants repeated the process after 8 weeks of SIT (3 × 20 s 'all-out' sprints, 2 × a week). Total CPCs (CD34 ) and endothelial progenitor cells (EPCs: CD34 KDR ) were determined by flow cytometry. Older adults exhibited lower basal total CD34 CPCs (828 ± 314 vs. 1186 ± 272 cells·mL , p = 0.0149) and CD34 KDR EPCs (177 ± 128 vs. 335 ± 92 cells·mL , p = 0.007) than younger adults. The maximal exercise test increased CPCs in young (CD34 : p = 0.004; CD34 KDR : p = 0.017) and older adults (CD34 : p < 0.001; CD34 KDR : p = 0.008), without difference between groups (p = 0.211). SIT did not alter resting or exercise-induced changes in CPCs in the older cohort (p > 0.232). This study suggests age per se does not impair exercise-induced CPC counts, but does lower resting CPC counts.

Item Type:	Article
Journal / Publication Title:	Pflügers Archiv European Journal of Physiology
Publisher:	Springer
ISSN:	1432-2013
Departments:	Institute of Health > Rehabilitation and Sport Science Active Aging Research Group (AARG)
Additional Information:	Zerbu Yasar received a PhD scholarship from the University of Cumbria. Lawrence D. Hayes received research funding from the University of Cumbria for data generation.
Depositing User:	Insight Administrator
SWORD Depositor:	Insight Administrator
Date Deposited:	28 Feb 2023 13:18
Last Modified:	13 Jan 2024 14:32
URI:	https://insight.cumbria.ac.uk/id/eprint/6926

Downloads