Endoglin expression in early development is associated with vasculogenesis and angiogenesis

Jonker, Leon ORCID logo ORCID: https://orcid.org/0000-0001-5867-4663 and Arthur, Helen M. (2001) Endoglin expression in early development is associated with vasculogenesis and angiogenesis. Mechanisms of Development, 110 (1). pp. 193-196.

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Official URL: https://doi.org/10.1016/S0925-4773(01)00562-7


Endoglin is an auxiliary receptor for the transforming growth factor-β family of cytokines and is required for angiogenesis and heart development. Endoglin expression during mouse embryogenesis was analysed by monitoring β-galactosidase expression from a lacZ reporter cassette inserted downstream of the endoglin promoter. Expression was first detected at 6.5 days post-coitum (dpc) in the amniotic fold and developing allantois. Between 7.5 and 8.5 dpc, endoglin was expressed in endothelial cells of the yolk sac, dorsal aorta and primitive heart tube, and from 9.5 to 13.5 dpc in endothelial cells throughout the developing vasculature. Interestingly, this pattern of endoglin expression is almost identical to that reported for Alk1.

Item Type: Article
Journal / Publication Title: Mechanisms of Development
Publisher: Elsevier
ISSN: 0925-4773
Departments: Institute of Health > Medical Sciences
Depositing User: Insight Administrator
Date Deposited: 21 Jan 2022 09:39
Last Modified: 11 Jan 2024 18:15
URI: https://insight.cumbria.ac.uk/id/eprint/6345


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