Open-label, randomised, multicentre crossover trial assessing two-layer compression bandaging for chronic venous insufficiency: results of the APRICOT trial

Jonker, Leon ORCID: https://orcid.org/0000-0001-5867-4663 , Todhunter, Jane, Robinson, Lesley and Fisher, Stacey (2020) Open-label, randomised, multicentre crossover trial assessing two-layer compression bandaging for chronic venous insufficiency: results of the APRICOT trial. British Journal of Community Nursing, 25 (Sup6). S6-S13.

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Abstract

Background Compression bandaging is the mainstay therapy for chronic venous insufficiency and venous leg ulcers, but patient compliance can be challenging due to associated discomfort.
Aims Comparison of AndoFlex® TLC Calamine versus Coban2® compression bandaging in relation to patient comfort and related pruritus symptomology, with severity of pruritus scale as primary outcome.
Methods Multi-centre, prospective, non-blinded, randomised controlled crossover trial involving 39 randomised participants. Two periods for chronic venous insufficiency patients, to wear either AndoFlex® TLC Calamine or Coban2® for three weeks each.
Findings No significant differences in validated pruritus outcome measures were observed, including a non-significant treatment effect for the severity of pruritus scale (n = 35 trial completers, p-value 0.24, Wilcoxon test). However, after trying both bandages, 21 out of 35 patients (60%) definitely preferred AndoFlex® TLC Calamine whereas 4 patients (11%) definitely preferred Coban2®.
Conclusion AndoFlex® TLC Calamine compression bandage therapy is preferred by the majority of patients, although this observation could not be confirmed using validated patient-reported outcome measures for pruritus. Further research is indicated to establish if patient preference translates into favourable clinical outcomes.

Item Type:	Article
Journal / Publication Title:	British Journal of Community Nursing
ISSN:	1462-4753
Departments:	Academic Departments > Medical & Sport Sciences (MSS) > Health and Medical Sciences
Depositing User:	Christian Stretton
Date Deposited:	22 Jun 2020 13:29
Last Modified:	13 Jan 2024 11:01
URI:	https://insight.cumbria.ac.uk/id/eprint/5588

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