CYP2C8 Polymorphisms among malaria patients in Guinea-Bissau

Khoo, Yvonne J-Lyn (2008) CYP2C8 Polymorphisms among malaria patients in Guinea-Bissau. In: 2nd Health and Medical Sciences Conference / 2nd Penang International Postgraduate Convention: Chemical Biology, Innovative Exploration of New Horizons in Science, 18-20 June 2008, University of Science, Malaysia. (Unpublished)

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Abstract

Malaria is one of the major public health problems in more than 90 countries, inhabited by a total of some 2.4 billion people, representing about 40% of the world’s population (WHO, 2004). Amodiaquine (AQ) has been recently introduced into artemisinin-based combination therapy for use in malaria control programmes and as a first line treatment for children with uncomplicated malaria (WHO, 2006). Besides amodiaquine, CYP2C8 also metabolizes several therapeutically important drugs and endogenous substances including: paclitaxel, verapamil, rosiglitazone, cerivastatin, amiodarone, dapsone, all-trans-retinoic acid, arachidonic acid. Research objectives: To study CYP2C8 alleles among malaria patients from Guinea Bissau; To assist policy-makers in the management of malaria in Guinea-Bissau; To generate pharmacogenetic data for the evaluation of treatment and drug dispension; To contribute findings to other databases and bio-banks within and outside Europe; To allow further comparisons with other populations previously characterized in the Center for Molecular and Structural Biomedicine, Universidade do Algarve, Portugal.

Item Type: Conference or Workshop Item (Paper)
Departments: Rehabilitation
Additional Information: Jae-Llane Ditchburn, née Yvonne J-Lyn Khoo.
Depositing User: Anna Lupton
Date Deposited: 12 Jul 2019 12:53
Last Modified: 23 Jul 2019 01:06
URI: http://insight.cumbria.ac.uk/id/eprint/4994

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