Nonhuman primates across sub-Saharan Africa are infected with the yaws bacterium Treponema pallidum subsp. pertenue

Knauf, Sascha ORCID logo ORCID: , Gogarten, Jan F., Schuenemann, Verena J., De Nys, Hélène M. ORCID logo ORCID: , Düx, Ariane, Strouhal, Michal, Mikalová, Lenka, Bos, Kirsten I., Armstrong, Roy ORCID logo ORCID: , Batamuzi, Emmanuel K., Chuma, Idrissa S., Davoust, Bernard, Diatta, Georges, Fyumagwa, Robert D., Kazwala, Reuben R., Keyyu, Julius D., Lejora, Inyasi A.V., Levasseur, Anthony, Liu, Hsi, Mayhew, Michael ORCID logo ORCID: , Mediannikov, Oleg, Raoult, Didier, Wittig, Roman M., Roos, Christian, Leendertz, Fabian H., Smajs, David, Nieselt, Kay, Krause, Johannes and Calvignac-Spencer, Sébastien (2019) Nonhuman primates across sub-Saharan Africa are infected with the yaws bacterium Treponema pallidum subsp. pertenue. Emerging Microbes and Infections, 7 (1).

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Dear Editor, The bacterium Treponema pallidum (TP) causes human syphilis (subsp. pallidum; TPA), bejel (subsp. endemicum; TEN), and yaws (subsp. pertenue; TPE) (1). Although syphilis has reached a worldwide distribution (2), bejel and yaws have remained endemic diseases. Bejel affects individuals in dry areas of Sahelian Africa and Saudi Arabia, whereas yaws affects those living in the humid tropics (1). Yaws is currently reported as endemic in 14 countries, and an additional 84 countries have a known history of yaws but lack recent epidemiological data (3,4). Although this disease was subject to global eradication efforts in the mid-20th century, it later reemerged in West Africa, Southern Asia, and the Pacific region (5). New large-scale treatment options triggered the ongoing second eradication campaign, the goal of which is to eradicate yaws globally by 2020 (5).

(1) Giacani, L. & Lukehart, S.A. The endemic treponematoses. Clin. Microbiol. Rev. 27, 89–115 (2014).
(2) Arora, N. et al. Origin of modern syphilis and emergence of a pandemic Treponema pallidum cluster. Nat. Microbiol. 2, 16245 (2016).
(3) Marks, M. Yaws: towards the WHO eradication target. Trans. R Soc. Trop. Med. Hyg. 110, 319–320 (2016).
(4) World Health Organization. Eradication of yaws: procedures for verification and certification of interruption of transmission (World Health Organization, Geneva, 2018).
(5) Asiedu, K., Fitzpatrick, C. & Jannin, J. Eradication of yaws: historical efforts and achieving WHO’s 2020 target. PLoS Negl. Trop. Dis. 8, e3016 (2014).

Item Type: Article
Journal / Publication Title: Emerging Microbes and Infections
Publisher: Nature Publishing Group for Shanghai Shangyixun Cultural Communication Company
ISSN: 2222-1751
Departments: Centre for National Parks and Protected Areas (CNPPA)
Additional Information: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Michael A. Mayhew, Department of Science, Natural Resources and Outdoor Studies, University of Cumbria, UK.
Depositing User: Michael Mayhew
Date Deposited: 11 Sep 2018 08:48
Last Modified: 13 Jan 2024 08:17


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