Determining the contribution of IL33 and IL1RL1 polymorphisms to clinical and immunological features of asthma

Portelli, Michael A., Bennett, Neil D., Hankinson, Jenny, Ntalla, Ioanna, Henry, Amanda, Billington, Charlotte K., Shaw, Dominick, Pogson, Zara E.K., Fogarty, Andrew, McKeever, Tricia, Jonker, Leon, Singapuri, Amisha, Heaney, Liam, Mansur, Adel, Thomson, Neil C., Chaudhuri, Rekha, Holloway, John, Lockett, Gabrielle, Howarth, Peter, Niven, Rob, Tobin, Martin D., Wain, Louise V., Hall, Ian P., Brightling, Chris E., Simpson, Angela and Sayers, Ian (2016) Determining the contribution of IL33 and IL1RL1 polymorphisms to clinical and immunological features of asthma. American Journal of Respiratory and Critical Care Medicine, 193 . A2922. Full text not available from this repository.

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Official URL: http://www.atsjournals.org/doi/abs/10.1164/ajrccm-...

Abstract

Rationale: IL33 (9p24.1) and the IL33 receptor (IL1RL, 2q12) have been reproducibly identified as asthma susceptibility genes. However, the variants driving genetic associations are not yet fully defined. Using a population based birth cohort of 1059 children (Manchester Asthma and Allergy Study-(MAAS)) and 2536 adults with asthma (Genetics of Asthma Severity and Phenotypes- (GASP)) cohort we aimed to define genetic variants associated with clinical and immunological features of asthma.

Item Type: Article
Journal or Publication Title: American Journal of Respiratory and Critical Care Medicine
Publisher: American Thoracic Society
ISSN: 1535-4970
Departments: Faculty of Health and Science > Health, Psychology and Social Studies
Depositing User: Anna Lupton
Date Deposited: 13 Jul 2017 13:36
Last Modified: 01 Dec 2017 09:57
URI: http://insight.cumbria.ac.uk/id/eprint/3097

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