Normal pressure hydrocephalus and cerebral blood flow: a PET study of baseline values

Owler, Brian K., Momjian, Shahan, Czosnyka, Z., Czosnyka, M., Pena, Alonso, Harris, Neil G., Smielewski, P., Fryer, T., Donovan, Tim, Coles, Jonathan, Carpenter, A. and Pickard, J.D. (2004) Normal pressure hydrocephalus and cerebral blood flow: a PET study of baseline values. Journal of Cerebral Blood Flow & Metabolism, 24 (1). pp. 17-23. Full text not available from this repository.

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Official URL: http://www.nature.com/jcbfm/journal/v24/n1/full/95...

Abstract

Regional cerebral blood flow (CBF) was studied with O15-water positron emission tomography and anatomic region-of-interest analysis on coregistered magnetic resonance in patients with idiopathic (n = 12) and secondary (n = 5) normal pressure hydrocephalus (NPH). Mean CBF was compared with values obtained from healthy volunteers (n = 12) and with clinical parameters. Mean CBF was significantly decreased in the cerebrum and cerebellum of patients with NPH. The regional analysis demonstrated that CBF was reduced in the basal ganglia and the thalamus but not in white matter regions. The results suggest that the role of the basal ganglia and thalamus in NPH may be more prominent than currently appreciated. The implications for theories regarding the pathogenesis of NPH are discussed.

Item Type: Article
Journal or Publication Title: Journal of Cerebral Blood Flow & Metabolism
Publisher: Nature Publishing Group
ISSN: 1559-7016
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Departments: Faculty of Health and Science > Medical and Sports Sciences > Health and Medical Sciences
Depositing User: Insight Administrator
Date Deposited: 14 Oct 2011 14:56
Last Modified: 26 Aug 2016 16:09
URI: http://insight.cumbria.ac.uk/id/eprint/1035

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